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Heterologous Boosters
#1
A new NIH-sponsored study has been posted.  The study has a lot more than what is in the media today, but I haven't had a chance to digest it. (For instance, adverse events)  

The study is ongoing.  Neutralization results for the Delta variant were only available for Moderna. (Otherwise, neutralization results were for an early COVID version (WA-1).)

This must have been rushed out.  There are tables with data from 15-days post-booster but "in process" for 29-days post-booster.   Perhaps the FDA had this rushed so they could make a decision on the Moderna booster.

NPR:

Quote:People who got the Moderna vaccine for their original shots and Moderna again for their booster appear to have gotten the best immune response, followed by those who got Pfizer boosted by Moderna and then Moderna boosted by Pfizer — although the increase in immune response with the mRNA vaccines was probably too small to really make a difference in protection in most groups.

The most significant finding suggested that people who initially got the J&J vaccine seem to have gotten the best response if they got Pfizer or Moderna as their booster.


NOTE: This study used a 100mg (full) dose of Moderna as a booster.   Moderna has applied to the FDA for a 50mg (half) dose of Moderna as a booster.

I notice in the study that those that got the Moderna boost had a shorter interval after their first vaccinations until the boost (basically 14-17 weeks versus 20-24 weeks for Pfizer and 18-21 for J&J).  This is noticeable in the neutralizing titers prior to booster (original Moderna vaccine patients:  Moderna booster (16.4 weeks): 88.7; J&J booster (19.3 weeks): 61.7;  Pfizer booster (22.9 weeks): 57.6).  This makes me a little leary of their multiplicative factor as a measure of how effective the boost was.

I also don't believe this study can give a good idea of how enduring the effectiveness is.

However, the boost is quite significant for the mRNA boosters.  The J&J boost for J&J takes a low number and makes it a bit better -- sorta like an fading Pfizer and not as good as a fading Moderna.
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Messages In This Thread
Heterologous Boosters - by M_T - 10-13-2021, 05:02 PM
RE: Heterologous Boosters - by M_T - 10-13-2021, 05:52 PM
RE: Heterologous Boosters - by Hurlburt88 - 10-19-2021, 02:32 PM
RE: Heterologous Boosters - by M_T - 10-20-2021, 10:38 AM
RE: Heterologous Boosters - by Hurlburt88 - 10-23-2021, 06:17 AM
RE: Heterologous Boosters - by M_T - 10-27-2021, 04:36 PM
RE: Heterologous Boosters - by 82Card - 10-28-2021, 12:49 PM
RE: Heterologous Boosters - by M_T - 03-23-2022, 04:38 AM
RE: Heterologous Boosters - by M_T - 03-30-2022, 01:19 PM
RE: Heterologous Boosters - by ChrisGreene - 04-01-2022, 08:36 AM
RE: Heterologous Boosters - by M_T - 04-01-2022, 01:13 PM

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