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Biden & Single shot/Delayed Second Shot
Very cool. A Stanford paper published on Jan 4 advocated for the earlier release of reserved doses to be used as accelerated first doses “while enabling most to receive second doses on schedule.”

An Alternative Dose Distribution Of Tight COVID-19 Vaccine Supply

SHP's Joshua Salomon and colleagues offer an alternative approach to COVID-19 vaccine distribution — modeling a flexible strategy that would result in an additional 23% to 29% of COVID-19 cases averted compared with the current fixed strategy.

With concerns mounting about surging COVID-19 infections, the emergence of a more contagious variant, and sluggish distribution of new vaccines, SHP’s Joshua Salomon and colleagues have mapped out a way to gain more benefit from the first available doses of the Pfizer and Moderna COVID-19 vaccines.

Last month, the U.S. Food and Drug Administration issued an Emergency Use Authorization for the Moderna and Pfizer-BioNTech COVID-19 vaccines — a result dubbed “a miracle” by some health-care analysts as clinical trials for new vaccines typically take up to three years before they are approved for manufacture and distribution.

Although trial evidence for both vaccines indicate partial protection against COVID-19 illness after just one dose, both vaccines are authorized only in as two-dose series and have not yet been evaluated for single-dose use. So, in the United States, national distribution plans for the vaccine call for initially withholding 50% of the supply from states, only to be released three weeks later for use as second doses.

With the surge of COVID-19 cases nationwide, however, the researchers argue in their study published Jan. 4 in the Annals of Internal Medicine that this conservative approach delays giving the first doses to many who could gain substantial health benefits from earlier vaccination, such as the elderly, essential workers and those with pre-existing conditions and comorbidities.

“Current policies place a premium on eliminating any possible delays to delivering second doses,” Salomon and his colleagues write. “We find that under most plausible scenarios, a more balanced approach that withholds fewer doses during early distribution in order to vaccinate more people as soon as possible could substantially increase the benefits of vaccines, while enabling most to receive second doses on schedule.

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Biden & Single shot/Delayed Second Shot - by M_T - 01-09-2021, 05:25 AM
RE: Biden & Single shot/Delayed Second Shot - by Snorlax94 - 01-13-2021, 03:47 PM

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