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Comparison of Vaccines
#8
The referenced paper is
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

The article misrepresents the paper somewhat when it says: "these cells last for up to six months after vaccination"
The paper says "S-specific TFH persist at nearly constant frequencies for at least six months."

Quote:Indirect evidence has existed for some time that robust CD4+ T cell responses are required for the generation of high-titer neutralizing antibody responses following COVID-19 infection or mRNA vaccination. This includes data showing a lack of seroconversion in individuals with uncontrolled HIV and extremely low CD4+ T cell counts during vaccination (Touizer et al., 2021) as well as several reports that have demonstrated a lack of seroconversion to the standard two-dose BNT162b2 regimen in individuals subjected to T cell-focused immunosuppressive regimens following solid organ transplantation (Kamar et al., 2021). Our current results provide strong and direct evidence that a high-magnitude, antigen-specific CD4+ T cell response in the draining lymph nodes is present during the development of high-titer neutralizing antibody responses in the setting of COVID-19 mRNA vaccination.
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Messages In This Thread
Comparison of Vaccines - by M_T - 05-19-2021, 04:14 AM
RE: Comparison of Vaccines - by Hurlburt88 - 10-27-2021, 11:08 AM
RE: Comparison of Vaccines - by M_T - 10-27-2021, 05:44 PM
RE: Comparison of Vaccines - by Hurlburt88 - 10-28-2021, 11:24 AM
RE: Comparison of Vaccines - by Hurlburt88 - 11-29-2021, 12:15 PM
RE: Comparison of Vaccines - by M_T - 11-30-2021, 02:48 AM
RE: Comparison of Vaccines - by Hurlburt88 - 12-25-2021, 08:29 AM
RE: Comparison of Vaccines - by M_T - 12-28-2021, 01:15 AM

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