The referenced paper is
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
The article misrepresents the paper somewhat when it says: "these cells last for up to six months after vaccination"
The paper says "S-specific TFH persist at nearly constant frequencies for at least six months."
SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans
The article misrepresents the paper somewhat when it says: "these cells last for up to six months after vaccination"
The paper says "S-specific TFH persist at nearly constant frequencies for at least six months."
Quote:Indirect evidence has existed for some time that robust CD4+ T cell responses are required for the generation of high-titer neutralizing antibody responses following COVID-19 infection or mRNA vaccination. This includes data showing a lack of seroconversion in individuals with uncontrolled HIV and extremely low CD4+ T cell counts during vaccination (Touizer et al., 2021) as well as several reports that have demonstrated a lack of seroconversion to the standard two-dose BNT162b2 regimen in individuals subjected to T cell-focused immunosuppressive regimens following solid organ transplantation (Kamar et al., 2021). Our current results provide strong and direct evidence that a high-magnitude, antigen-specific CD4+ T cell response in the draining lymph nodes is present during the development of high-titer neutralizing antibody responses in the setting of COVID-19 mRNA vaccination.