![]() |
Antibodies for vaccinated with/without natural infection - Printable Version +- theCOVIDboard (https://thecovidboard.createmybb4.com) +-- Forum: COVID-19 (https://thecovidboard.createmybb4.com/forum-1.html) +--- Forum: Research (https://thecovidboard.createmybb4.com/forum-4.html) +--- Thread: Antibodies for vaccinated with/without natural infection (/thread-204.html) |
Antibodies for vaccinated with/without natural infection - M_T - 12-12-2021 Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses Quote:However, we show that Delta breakthrough cases, subjects who were vaccinated after Graph A shows the level of antibodies over time (30, 60, ... days) B, C, and D show different kinds antibodies at the same time (shortly after infection or vaccination) A thru D are measures of how effective the antibodies were against one particular culture of COVID. E and F are the same graph as D but against two other cultures of COVID. In each graph are different groups of people. Purple triangles are vaccinated people that got Delta (so probably recently). The cyan diamonds are people who were infected with COVID (original or other) and then got vaccinated. The orange circles are people who have been vaccinated but not had COVID. The gray squares are people that were infected (in WA in 2020) but not vaccinated. The white circles are people that were not vaccinated and not had COVID. 2X means two vaccinations. 3X means three vaccinations ![]() Quote:Figure 1: Repeated exposures to SARS-CoV-2 antigens through vaccination or infection enhance S-specific serum IgG and IgA binding titers. RE: Antibodies for vaccinated with/without natural infection - Hurlburt88 - 12-13-2021 interesting stuff! I am vaccinated and have booster, and before leaving for airport this morning took at-home test (which I have been doing all fall before travel) and it was positive (only symptom is slightly stuffy nose). So I am hoping this is nothing more than a tune-up for my immune system! RE: Antibodies for vaccinated with/without natural infection - M_T - 12-14-2021 Good for you for taking a test before going to the airport. The US is now encouraging tests on the day of mixing in public (for unvax for public events). I haven't seen but news reports that Omicron gets virulent faster. If so, that could help explain its infectiousness. And, of course, we all hope your case remains mild. California is again requiring masks for all people at public gatherings. I have 2 relatives that are showing cold-type symptoms (one with fever) 2 days after attending an unmasked party. I'm wondering if there are any testing services that identify Omicron (separately from Delta). A quick look didn't show any. There are definitely tests that do, but I don't know whether if they go to, say CVS, for a test, whether that testing service's tests identify Omicron or just simply identify COVID. Knowing nothing more than you are a "breakthrough" case, I'd guess you have a good chance that you got Omicron. CDC reports that 3% of the US cases (0.9% of California) now are Omicron. They didn't say what % of breakthrough cases are Omicron. RE: Antibodies for vaccinated with/without natural infection - Hurlburt88 - 12-14-2021 I took at PCR test at Walgreen's today to confirm or refute the at-home test. Obviously from that they can determine if Omicon or Delta, but I have no idea if they will tell me. If they do, I will post. And my symptoms have remained VERY mild--just a slight runny nose. Separately, does anyone reading this board know how long after infection the PCR tests continue to show positive? I remember something about it could be up to 90 days . . . (OK, I am officially guilty of thread drift) RE: Antibodies for vaccinated with/without natural infection - M_T - 12-15-2021 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532802/ Quote:Out of 155 American patients having undergone a PCR-based control subsequent to an initial positive finding, 88% remained positive 1 to 5 days later, and 56% out of the 105 patients tested afterwards remained positive at 21–25 days [6]. Median PCR negativation time in the 56 patients of the Chinese series by Xiao et al. was 24 days [7]. In Wuhan, 36/378 (9.5%) of patients having tested positive remained positive 30 days later, and in some cases their positivity lasted as long as 83 days [8]. The more severe the clinical presentation, the longer the duration of positivity, with a median of 31 days in a Chinese study involving 41 serious cases [9]. In a Singaporean study, 32% out of 766 COVID19 patients still remained positive at D21, 22% at D28 and 5% at D33 See also https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417974/ https://www.news-medical.net/news/20210615/Analysis-of-COVID-19-patients-with-repeatedly-positive-SARS-CoV-2-tests.aspx As a reminder, initially the CDC recommended a negative test to show one is over the disease. Then they switched to 10 days after symptom onset, presumably partly because of continued positive tests. For COVID-19 isolation recommendations, see https://www.cdc.gov/coronavirus/2019-ncov/your-health/quarantine-isolation.html#isolation RE: Antibodies for vaccinated with/without natural infection - Hurlburt88 - 12-16-2021 Much appreciated! |