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GlaxoSmithKline plant-based COVID vaccine - Mick - 05-18-2021

https://www.marketwatch.com/story/a-plant-based-vaccine-from-a-glaxosmithkline-alliance-with-medicago-shows-strong-antibody-response-11621349865

Ten times the COVID-19 antibodies that infected/recovered people have.  Is the result the same for other vaccines?


RE: GlaxoSmithKline plant-based COVID vaccine - M_T - 05-19-2021

The GSX press release had   "about 10 times higher than those in a panel of sera from patients recovering from COVID-19"

Ah... here are the details. on CoVLP+AS03
After 2 doses, at day 42, the neutralizing antibody (NAb) titers were roughly 2000 for both adults and older adults.

I found a comparison of the 9 vaccines approved somewhere in the world.
It reports neutralizing antibody titer for Moderna as 654 and Pfizer as 361.  
It reports the Novavax NVX-CoV2373 NAb titer as 3906
and the Clover SCB-2019 NAb titer as 1810-3320.

I do NOT know that simply having a higher NAb titer is sufficient to indicate it is a better vaccine.  Obviously safety ia major factor.  Also, there is an issue about being effective against variants.

"The vaccine candidate developed by Medicago, a Coronavirus-like particle (CoVLP), is a self-assembling VLP [virus-like particle] that displays trimers of recombinant S protein of SARS-CoV2 embedded into the lipid bilayer of the nanoparticles."