Correspondence to the NEJM: Plasma Neutralization of the SARS-CoV-2 Omicron Variant 
The results are pretty much what I've already seen.

I find the presentation of the content, uh, disorganized.  Maybe it is best to go to the PDF and download it, and just look at the graphs

I find it disturbing that the two rows of graphs have different vertical scales (so it is easy to compare across row A or row B, but you have to check the numbers to compare between row A and B).  I would ignore the PMS20 numbers.

Most of us will be row B (mRNA + Booster):
Even (with plasma from) 1 month after 2nd mRNA, the protection against Omicron was quite low (compared to against the original strain).  However, the low level didn't drop much from month 1 to month 5 (but was still very much lower (133x or so) than against the original strain).  A booster upped the level of protection very significantly against Omicron, well beyond what it was at 1 month.  It actually starts to get close to the protection levels of the mRNA vaccines against the original strain at 6 months after the 2nd.

You can also see that a natural infection of the original strain + mRNA vaccine was pretty equivalent to just getting the vaccine when looking at effectiveless against Omicron.

The J&J vaccine didn't have a measurable effect, so it isn't shown.

How bad is it?  Where on the exponential curve do you want to be?

Covid detection in Santa Clara County wastewater.
This data starts in Oct. 2020. You'll have to click on the thumbnail to see the recent data.
Note how steep the growth is in the last week.


Covid detection in Massachusetts wastewater:
Here's the detection from March 2020 until Dec. 2021.  You see the initial wave, then the wave last winter, and then in September, the Delta wave.
 
Go ahead, click on the image to see the full graph as the thumbnail is missing the right-hand edge.


And here's the data as of December 30.  I'm afraid you'll have to click on it too.


Buckle up!  It is going to be a wild start to 2022.

(12-25-2021, 10:55 AM)Hurlburt88 Wrote: I don't know if I got Omicron or Delta, but 12 days ago I tested at home before travel and was positive.   Ended up with runny nose and nothing else.  Wife and other contacts all tested negative.  

Hope you are yours don't develop any serious symptoms, Mick!

My wife and I have very, very mild symptoms.  Runny nose, little bit of lethargy.  I've lost my sense of smell in a very narrow range, most of it is intact.

My sister-in-law (Stanford, '89) got it pretty bad.  She and her husband are in bed.  Their five year old tested positive.  All are doing well.

I'm glad you are doing well. Are you willing to say if the two that got it bad (or their child) were vaccinated?

A close relative visited & stayed with child & grandkids who developed a upper respiratory infection just before Christmas. It hit the child(parent) and one grandchild (too young to be vaccinated) pretty hard, while the other child just had sniffles one day. But the grandparent got hit hardest & developed pneumonia & hospitalized for 2 days. This was NOT Covid. The kids brought the infection into the household.

(01-02-2022, 04:51 PM)M_T Wrote: I'm glad you are doing well.  Are you willing to say if the two that got it bad (or their child) were vaccinated?

A close relative visited & stayed with child & grandkids who developed a upper respiratory infection just before Christmas.  It hit the child(parent) and one grandchild (too young to be vaccinated) pretty hard, while the other child just had sniffles one day.  But the grandparent got hit hardest & developed pneumonia & hospitalized for 2 days.  This was NOT Covid.  The kids brought the infection into the household.

Adults had two Pfizer shots, no booster.  Kids hadn't had shots.